The study of organizational behavior Essay Example for Free

The study of organizational behavior Essay The study of organizational behavior is concerned with: A) psychosocial, interpersonal, and organizational structure B) interpersonal, group dynamics in organizations, and work design C) psychosocial, interpersonal, and work design D) psychosocial, interpersonal, and group dynamics in organizations Points Earned: Correct Answer(s): D 2. The beliefs and assumptions about people, work, and the organization best reflects the: A) social surface B) formal organization C) informal organization D) overt part of an organization Points Earned: Correct Answer(s): C 3. The task of an organization is reflected in its: A) mission, purpose or goal B) human resources C) input materials D) structure Points Earned: 1. 0/1. 0 Correct Answer(s): A 4. The science of human behavior and individual differences is: A) psychology B) sociology C) engineering D) anthropology 5. EXTRA CREDIT: What was your preferred learning style as indicated by the VARK Questionnaire? Also list one way you want to take in intormation according to your style. For the extra point you had to name your VARK learning style AND one way to take in information (according to VARK) Points Earned: 0. /0. 0 6. The internal or external perspectives offer: A) conflicting explanations for human behavior B) complementary explanations for human behavior C) alternative explanations for human behavior D) similar explanations for human behavior 7. The specific setting within which organizational behavior is enacted would be called the: A) external environment B) situation C) organizational context D) group Points Earned: 0. 0/1. 0 8. Culture and the study of learned behavior comprise the domain of: A) management B) psychology C) sociology 9 . All of the following are internal behavioral processes except: A) Judging B) perceiving C) leading D) cognition The four main driving forces creating and shaping changes at work include: A) globalization, demography, diversity, ethics B) globalization, technology, diversity, employee attitudes C) globalization, diversity, ethics, and technology D) globalization, technology, religiosity, ethics 11. The description of an organization as clockworks, in which human behavior is logical and rational, would come from which level within the organization? A) organizational level B) internal level C) group or department level D) individual level The work of Hofstede is important because his studies revealed that more differences n work-related attitudes can be explained by: A) culture B) age C) gender D) profession The major difference between prejudice and discrimination is: A) prejudice refers to behavior and discrimination refers to an attitude B) discrimination has been shown to have more of an impact on productivity than prejudice C) prejudice has been shown to have more of an impact on productivity than discrimination D) prejudice refers to an attitude and discrimination refers to behavior Points Earned: 0. 0/1. According to your text, African-Americans and Hispanic-Americans are likely to be at disadvantage within organizations because: A) available Jobs in the tuture will require less skill than in the past B) they are under-represented in declining occupations C) the proportion of African-Americans and Hispanic-Americans who are qualified for higher level Jobs are often higher than the proportion of qualified whites and Asian- Americans D) they tend to live in a small number of large cities that are facing severe economic difficulties Points Earned: 0. 0/1. 0 Globalization implies all of the following except: A) a borderless world B) competition between workers from other countries C) an organizations nationality is held strongly in consciousness D) the world is free from national boundaries Which of the following was NOT recommended as a technique for increasing the sensitivity of differences between people from various cultures? A) describing one anothers culture B) cultural sensitivity training C) cross-cultural task forces or teams D) role analysis technique (RAT) Which statement best captures the spirit of managing diversity? A) It is a painful examination of hidden assumptions that employees hold. B) It is assimilating women and minorities into a dominant male culture. C) It is complying with affirmative action. D) It is being a good corporate citizen. Which of the following statements/statistics about women in the workforce is incorrect? A) There has been little increase in the number of women CEOs.

Pick a developing country Essay Example for Free

Pick a developing country Essay The Philippines is a Southeast Asian country composed of more than seven thousand and one hundred islands. Its capital is Manila and it’s a developing country with a population of about 90 million people. Filipinos, the people of the country, speak Filipino, the national language, and English. The country has a long history of colonialism, having been subject to the rule of three foreign nations: Spain, the United States, and Japan. These three colonial periods in the history of the country produced lasting effects on its culture, political system, economy, and geography. Although the Philippines has a long history of being a colony, its people had resisted colonizers when the interests of the country were endangered. The first colonizers of the country were the Spanish. It’s believed that nearby territories in Southeast Asia traded with the Philippine islands long before the Spanish came. The first recorded resistance against Spanish colonization occurred in 1521 when Spanish explorers, led by Ferdinand Magellan landed in Mindanao, the southernmost region of the country (Schirmer Shalom, 1987, p. 193). According to historians, the Spaniards claimed the islands as Spanish territory and violated the women of the natives. They also attempted to baptize the natives as Christians, resulting in the resistance of some of the natives. Native leaders then decided to make war with the Spaniards and consequently killed the crew members, including Magellan. The Philippine history of colonialism did not end with the death of Magellan, however. In 1565, the Spanish returned to the Philippine islands with superior imperialistic techniques and weaponry. Within ten years, most of the seven thousand one hundred islands of the country had fallen to Spanish rule (Schirmer Shalom, 1987, p. 193). Through coordinated resistance movements across the country, the Philippines was able to break from Spanish rule in 1898, the first complete liberation of an Asian country from a European colonizer. Philippine independence though was short-lived because Americans, who fought the Spaniards to free Cuba, eventually annexed the archipelago as part of their strategy to achieve global dominance (Go Foster, 2003, p. 148). Filipinos resisted their colonization by the United States, resulting in the Philippine-American war. The US tried to suppress the resistance of Filipinos through various techniques, including the establishment of a US government in the country. Just as the US and the Philippines were finishing plans for independence, however, Japan invaded the country during World War II. The Philippines and the US, now working together, defeated the Japanese colonizers in 1944. The US granted the Philippines its independence in 1946 . Today, the Philippines still bears the unmistakable marks of its long history of colonialism. The Filipino language, which is mostly composed of the native dialect of Tagalog, includes many Spanish terms. Words like â€Å"mesa† (table), â€Å"libro† (book), â€Å"lugar† (place), and â€Å"kalye† from the Spanish â€Å"calle† (road) are just some examples of the Spanish language’s impact on the native tongue (Schirmer Shalom, 1987, p. 204). It’s not only in the Filipino language that the long Spanish rule is evident, however. Many elements of Filipino culture have traces of Spanish colonization. For instance, many Filipino families today still practice the Spanish siesta or sleeping during the afternoon. Traditional Philippine clothes like the â€Å"camisa de chino† for men and the â€Å"baro’t saya† for women look like derivatives of traditional Spanish dresses. While the Spaniards ruled the Phillipine islands for the longest time among all other colonizers, Americans perhaps have the deepest impact on the culture of the country. Today, many Filipinos, including the government, treasure the supposed friendship of the Philippines with the United States. The Philippine government has constant contact with the US government and is very vocal about its support of US policies and stands on global issues. The English language is spoken or at least understood by most Filipinos living in the country. Hollywood films do not need to be translated to the Filipino language in order for locals to understand the content. Malls in the country are lined with American shops which many Filipinos frequent. The local media is filled with American films and songs which people tune in to every day. In fact, many Filipinos learn the English language through the media and not through schools, although the English language is taught in elementary and high school (Go Foster , 2003, p. 198). The Philippine government also derives many things from its American counterpart. The government has a President, Senate, House of Representatives and judiciary arm. It is protected by an armed force with the president as its commander-in-chief. Perhaps the most glaring difference between the Philippine and the US government is that the former does not adopt the federal system. Charter change movements in the country recently however, are trying to change that to adopt the federal system (Go Foster, 2003, p. 153). Since the Japanese colonization of the Philippines was short-lived, it left few lasting impacts on the country. The Japanese government still supports the victims of its invasion today, though, especially the veterans of the war and its victims. The Japanese colonization of the country is taught at history classes, ensuring the awareness of young Filipinos of their unfortunate past with Japan (Ikehata Yu-Jose, 2003, p. 328). Past wounds have made the Philippines a very open country to all nations and races of the world. Many Filipinos today love Japanese culture, which is exported to the country mostly in the form of anime (Japanese animation) and computer products. The Philippine government also works together with the Japanese government to improve the lives of citizens (Ikehata Yu-Jose, 2003, p. 328). The geography of the country also bears many marks of colonialism. Manila became the capital city of the country mainly due to the fact that it has ports that welcome ships from other territories. Manila though is not the most prosperous city in the Philippines today. Quezon City, also located in the national capital region, has a wider area and grows at a tremendous pace. Makati City, the Philippine business center, is dotted with skyscrapers that house many multinational companies that do business in the country (Espiritu, 2003, p. 23). The Philippines is a rich source for cheap and skilled labor for many developed countries worldwide because of the Filipinos’ mastery of the English language. There is a booming outsourcing and call center industry in the country which provide young Filipinos with stable jobs. It’s very convenient for American companies to hire call center agents in the country because Filipinos know the English language by heart. Compared to other sources of labor in the world, Filipinos are easy to train to adopt the American English accent. Filipinos are also known as hard-working individuals, making them tempting investments to multinational companies (Espiritu, 2003, p. 23). Resistance though doesn’t disappear even in this age of friendship with past colonizers. There are still many social movement groups in the country that promote the interests of the country by resisting the influence of the United States and other foreign nations. These nationalistic groups follow developments in the government to ensure that Filipino interests are not compromised because of foreign interests or corruption within the government. Some of these groups also recruit members from schools and mobilize them through protests or demonstrations (Pomeroy, 1992, p. 25). The Philippines is now free but experts claim that modern forms of imperialism are still affecting many aspects of the country. Although the age of colonialism is over because the US and other foreign nations cannot put up governments in the Philippines anymore, their cultural influences are still felt by Filipinos as globalization speeds up. Accepting foreign influences in the culture, government and economy of the country is not necessarily disadvantageous to Filipinos, but it’s always best to focus on their own interests as a nation. The development of the Philippines will be faster once it learns to balance the lessons it learned from colonialism with the present realities it confronts. References Espiritu, Y. L. (2003). Home Bound: Filipino American Lives Across Cultures, Communities, and Countries. University of California Press. Go, J. and Foster, A. L. (2003). The American Colonial State in the Philippines: Global Perspectives. Duke University Press. Ikehata, S. and Yu-Jose, L. N. (2003). Philippines-Japan Relations. Ateneo de Manila University Press. Pomeroy, W. J. (1992). The Philippines: Colonialism, Collaboration, and Resistance. International Publishers Co. Schirmer, D. B. , Shalom, S. R. (1987). The Philippines Reader: A History of Colonialism, Neocolonialism, Dictatorship, and Resistance. South End Press.

Synthesis of Janus Nanocomposites for Drug Delivery System

Synthesis of Janus Nanocomposites for Drug Delivery System Over the past few decades, drug delivery systems have been well developed and studied to improve the curative effect of drugs.[1–4] Drug delivery systems can ameliorate the problems of conventional administration by prolonging duration time, enhancing drug solubility, retaining drug bioactivity, reducing side effect, and so on.[5, 6] A variety of carriers such as lipids,7, 8 polymer gels,[9,10] especially nanoparticles,11, 12 have been studied in drug delivery systems. At present, stimuli sensitive drug delivery systems have been an attractive theme for controlled release. The release behaviors of drugs can be easily controlled by surrounding properties, such as temperature,13, 14 pH,15,16 electric field,[17 ionic strength,[18 and so on. Recently, combined therapy with dual-drugs of different therapeutic effects shows excellent performance in treatment of diseases.19, 20 In order to optimize therapeutic effects, the doses and species of drugs should be optimized at different c linical manifestations and periods in the treatment. One of the main challenges of combined therapy is to control the release behavior of each drug independently. However, simple drug delivery systems cannot fulfill the needs of such therapy, because the most widely used carriers are normally possess single symmetrical geometry with single-surface. Even the dual-drugs are loaded on the single-surface carrier at same time, the delivery systems are designed only for the simultaneous release of two different drugs, and the release of each drug cannot be controlled. Furthermore, the multi-conjugates or loadings can interact with each other leading to undesired adverse effects. Therefore, developing independent multi-surface nanostructures for combination or loading of multiple drugs is critically desired. Janus nanoparticles possess multiple surface structures are anisotropic in composition, shape, and surface chemistry.[21] The structural asymmetry is ideally suited for dual-drug conju gations or loadings on different sections of a single Janus particle.[22] Furthermore, functionally distinct surfaces of the Janus particle can be used to selectively conjugate with specific chemical moieties for controlling the dual-drug loading or releasing, respectively.[23-25] During the past decades, considerable efforts have been made on the fabrication of Janus particles.[26-30] For instance, a monolayer of spherical particles such as those of polystyrene (PS) or silica colloidal nanospheres are spread on a solid substrate.[31-33] Thus, the functionalization could take place only on the top surfaces of the anchored particles. Because the low yield of the Janus particles result from the limited surface area of the bulk substrates, a modified method was later developed by using colloidal particles as the supporting substrates.[34-38] Another method for fabricating Janus particles was carried out at interfaces: a particle partially contacted with reactive medium and generated different surface functionalities from the opposite surface.36 With the development of microfluidic technique, Janus particles could also be fabricated by solidifying droplets composed of immiscible components.[39, 40] Other methods such as controlled surface nucleation, phase separat ion, and controllable polymer attachment,[41-54] have been also developed to synthesize the Janus particles. But the Janus particles reported previously were often close to micrometer in size and typically involved various types of polymers, which could induced poor biocompatibility, the fabrication of small Janus nanoparticles with inorganic materials is still a greater challenge.[48-54] On the other hand, the widely used silica is an useful material for building concentric [emailprotected] structures by using metallic or magnetic nanoparticles or quantum dots as cores,[55-57] but there have been few reports about silica based Janus nanoparticles. Due to the amorphous nature of silica, it is difficult to fine-tune the surface tension or lattice mismatch between silica and these core materials to form the Janus nanostructure. Feasibility for the synthesis of Janus nanocomposites As mentioned above, it is difficult to fine-tune the surface tension or lattice mismatch between silica and these core materials to form the Janus nanostructure due to the amorphous nature of silica. But for mesoporous silica materials, it has attracted a great deal of attention because of their versatility in surface tension and pore lattice parameters.[58, 59] In order to realize the formation of silica based Janus nanoparticles, the solution-grown synthesis route for the fabrication of inorganic nanocrystals based Janus (such as Au-Fe3O4,[60] Au-CdSe,[61] CdS-FePt,[62] Ag-Fe3O4,[63] CdSe-Fe3O4,[64] and so on) provides a possible clue to the creation of the silica based Janus nanoparticles by using the mesoporous silica as a structural subunit. The inorganic nanocrystals may have polymorphic atomic structures that are epitaxially attached at the interface from a core, leading to specific inorganic nanostructures with well-defined and characteristic shapes such as dimmers or trimers .[65, 66] For the growth of the ordered mesoporous structures, it is partly analogous to the growth of inorganic nanocrystals. Rather than epitaxy from atomic structures, the mesostructures can also be oriented by surfactants micelle and further induced the epitaxy growth of the mesoporous silica. So, compared with the formation of the inorganic nanocrystals Janus nanostructures, the silica based Janus nanocomposites would also be fabricated under the direction of the epitaxially growing properties of the mesoporous silica. Project proposal Focusing on the issues faced by the synthesis of the silica-based Janus nanocomposites and corresponding applications, this proposed project concerns the development of a novel anisotropic growth induced route for the synthesis of Janus core-shell mesoporous silica nanocomposites [[emailprotected]2@mSiO2-PMO (NCs = Functional nanocrystals; mSiO2= mesoporous silica; PMO= periodic mesoporous organosilicas)] by using the mesoporous silica as a structural subunit, and the obtained Janus nanocomposites can be used for dual-control drug release (ibuprofen and doxorubicin). As shown in Scheme 1, inorganic functional nanocrystals, including upconversion nanoparticles (UCNPs), magnetic nanoparticles (Fe3O4) and quantum dots (QDs), are firstly synthesized by using solvothermal approaches at a high temperature. Then, the [emailprotected]2 [emailprotected] nanoparticles, including [emailprotected]2, Fe3O4@SiO2, [emailprotected]2, will be synthesized with the reverse micro-emulsion method. Duo to the hydrophobic surface property of the obtained NCs, this hydrophilic SiO2 layer is very necessary for the following syntheses and applications. Furthermore, SiO2 layer can also serve as protective cover for the physical properties of the inorganic functional NCs, such as the fluorescences of UCNPs and QDs. Subsequently, the radial mesoporous SiO2 will be synthesized to form [emailprotected]2@mSiO2 [emailprotected]@shell nanostructures with the Stà ¶ber method in the presence of structure-directing agent (CTAB). The radial mesoporous layer of the obtained [emailpro tected]2@mSiO2 can accommodate the guest drug molecules (doxorubicin), the channel can also be easily modified with light sensitive switch molecules (azobenzene) by using post-modification method to realize the controllable release of doxorubicin. Finally, the Janus core-shell mesoporous silica nanocomposites of [emailprotected]2@mSiO2-PMO can be fabricated through a surfactant-templating approach by using cationic surfactant CTAB as a structure-directing agent and organic silica precursor as a source. At the very beginning, mesostructured CTAC/PMO composites can be assembled and deposited on the [emailprotected]2@mSiO2 nanoparticles surfaces. Then, through an anisotropic growth, the mesostructured shells finally develop into mesoscale single-crystals coated on the spherical [emailprotected]2@mSiO2 cores and form Janus nanocomposites. The mesoporous of PMO section of Janus nanocomposites can also accommodate the guest drug molecules (ibuprofen). By introducing the heat sensitive pha se-change material (1-tetradecanol) as switch molecules, it will realize the dual-control release of the guest species. As shown in Scheme 2, the dual-control (heat and NIR light) drug release (ibuprofen and doxorubicin) can be realized as following. Drug molecule (doxorubicin) loading in the [emailprotected]2@mSiO2 domains of the Janus nanocomposites: In this procedure, the inorganic functional nanocrystals are specified as NaGdF4:Yb, Tm UCNPs, which can emit photons in both UV (~ 350 nm) and Visible (~ 470 nm) region under NIR (980 nm) excitation. The mesopores of the [emailprotected]2@mSiO2 nanoparticles are modified with azobenzene molecules by using the post-modification method firstly. Both the loading and release of doxorubicin are regulated by the trans–cis photoisomerization of the azobenzene molecules. Specifically, the trans isomer of the azobenzene molecules will transform into the cis isomer under UV light irradiation, and in contrast the cis isomer will form the trans isomer under irradiation of visible light. The installing â€Å"photomechanical† azobenzene groups in the m esopores of silica are act as â€Å"stirrer† in the mesoporous silica, which can be used to control the loading and release of the drug. So, not only the release but also the loading of doxorubicin should be processed under the UV and visible light at the same time, and the drug will be locked in the mesopores of the [emailprotected]2@mSiO2 domains in the Janus structures after the UV and visible light are removed. The doxorubicin molecules absorb on the surface and mesopores of PMO domains in the Janus can be washed off with water. Drug molecule (ibuprofen) loading in the PMO section of the Janus nanocomposites and heat control release: After ibuprofen molecules are absorbed into the mesopores of PMO, the mesopores can be blocked with a phase-change material (1-tetradecanol), which has a melting point of 38 – 39 à ¯Ã¢â‚¬Å¡Ã‚ °C. Below 1-tetradecanol’s melting point, it will be in a solid state to completely block the passing of encapsulated ibuprofen. When the temperature is raised beyond its melting point, it will quickly melt to release the encapsulated ibuprofen (heat control release). NIR light control release of doxorubicin in the [emailprotected]2@mSiO2 section of the Janus nanocomposites: Upon absorption of NIR light (980 nm), the UCNPs can emit photons in the UV/Vis region, which are absorbed immediately by the photo responsive azobenzene molecules. The reversible photoisomerization by simultaneous UV and visible light emitted by the UCNPs creates a continuous rotation–inversion movement, and the doxorubicin molecules can be released from the mesopores of [emailprotected]2@mSiO2. Novelty of the project proposal: The anisotropic growth induced route for the synthesis of silica based multi-functional Janus core-shell mesoporous silica nanocomposites is proposed for the first time. Varieties of inorganic nanocrystals, including upconversion nanoparticles (UCNPs), magnetic nanoparticles (Fe3O4), quantum dots (QDs), can be introduced to further functionalize the Janus nanocomposites. Dual-control drug relase system based on mesoporous silica is proposed for the first time. The mesopore channels of [emailprotected]2@mSiO2 domains and PMO domains in multi-functional Janus nanocomposites can accommodate two kinds of drug molecules independently at the same time. Two kinds of switch molecules are design to realize dual-control release of the drug molecules independently for the first time. Task 1: Synthesis of the inorganic functional nanocrystals (NCs), including upconversion nanoparticles (UCNPs), magnetic nanoparticles (Fe3O4), quantum dots (QDs), and so on. The synthesis of the inorganic nanocrystals will be carried out at organic solvent with high boiling point solvents such as 1-octadecylen via a solvothermal approach at a high temperature (~ 300 à ¯Ã¢â‚¬Å¡Ã‚ °C for UCNPs, ~ 270 à ¯Ã¢â‚¬Å¡Ã‚ °C for Fe3O4 NCs, ~ 240 à ¯Ã¢â‚¬Å¡Ã‚ °C for QDs) in presence of the surfactants (oleic acid, oleylamine, etc.). Some simple inorganic salts such as rare earth chloride, iron acetylacetonate, iron oleate, cadmium oleate, zinc oleate, etc. will be used as the inorganic precursors. The necessary characterization (i.e. TEM, XRD, PL, UV-Vis, VSM) will be used in the experiments. Task 2: Fabrication of the [emailprotected]2 [emailprotected] nanoparticles, including [emailprotected]2, Fe3O4@SiO2, [emailprotected]2 and so on. Duo to the hydrophobic surface property of the obtained NCs, the [emailprotected]2 [emailprotected] nanoparticles will be synthesized with the reverse micro-emulsion method. The hydrophilic SiO2 layers in this objective are very necessary for the following syntheses and applications. Furthermore, SiO2 layers can also serve as a protective cover for the physical properties of the inorganic functional NCs, such as the fluorescences of UCNPs and QDs. Typically, the obtained inorganic NCs are dispersed in cyclohexane. Then polyoxyethylene (5) nonylphenyl ether (CO-520) and NH3.H2O are introduced to form reverse micro-emulsion. Finally, TEOS is introduced and hydrolysized at room temperature to form the [emailprotected]2 [emailprotected] nanoparticles. The necessary characterization (i.e. SEM and TEM) will be used in the experiments. Task 3: Fabrication of the [emailprotected]2@mSiO2 [emailprotected]@shell nanoparticles. In this step, the radial mesoporous SiO2 will be synthesized with the Stà ¶ber method in the presence of cationic surfactant such as CTAB. TEOS is used as a silica sources and hydrolysis in ethanol/water solution under alkaline condition (NH3.H2O) at room temperature. The necessary characterization (i.e. BET, SEM, and TEM) will be used in the experiments. Task 4: Fabrication of the Janus core-shell mesoporous silica nanocomposites ([emailprotected]2@mSiO2-PMO). The orientation growth of the cubic mesostructure of mesoporous organosilica (PMO) materials is the key factor for the formation of the silica-based Janus nanocomposites. In this step, organic silica precursors, such as bis(trieth-oxysilyl)benzene (BTEB), 1,2-bis(triethoxysilyl)ethane (BTEE), bis(triethoxysilyl) ethylene (BTEEE), are used as the silica sources and hydrolysis in ethanol/water solution under alkaline condition (NH3.H2O) at room temperature in the presence of CTAB templates. By adjusting experimental parameters, the organic silica precursors can cooperative self-assembly with surfactant CTAB to form the ordered cubic mesostructured PMO crystals. Because the different mesostructures between [emailprotected]2@mSiO2 (radial) and PMOs (cubic), the PMOs will epitaxy growth to form the [emailprotected]2@mSiO2-PMO Janus structure instead of the [emailprotected]2@mSiO2@PM O [emailprotected]@[emailprotected] structure. The necessary characterization (i.e. BET, XRD, SEM, FL, VSM and TEM) will be used in the experiment. Task 5: The design and evaluation of the dual-control drug release by using the obtained Janus core-shell mesoporous silica nanocomposites. The dual-control drug release can be realized as following. Drug molecule (doxorubicin) loading in the [emailprotected]2@ mSiO2 section of the Janus nanocomposites: In this procedure, the inorganic functional nanocrystals are specified as NaGdF4:Yb, Tm, UCNPs, which can emit photons in both UV (~ 350 nm) and Visible (~ 470 nm) region under NIR (980 nm) excitation. The mesopores of the [emailprotected]2@mSiO2 nanoparticles are post-modified with azobenzene molecules by using N-(3-triethoxysilyl)propyl-4-phenylazobenzamide in ethanol at 80 à ¯Ã¢â‚¬Å¡Ã‚ °C firstly. Both the loading and release of doxorubicin are regulated by the trans–cis photoisomerization of the azobenzene molecules. So, not only the release but also the loading of doxorubicin should be processed under the UV and visible light at the same time, and the drug will be locked in the mesopores of [emailprotected]2@mSiO2 domains in the Janus after the UV and visible light are removed. The doxorubicin molecules absorb on the surface and mesopores of PMO domains in the Janus can be washed off with water. Drug molecule (ibuprofen) loading in the PMO domains in the Janus nanocomposites and heat control release: After the ibuprofen molecules are absorbed into the mesopores of PMO, the mesopores can be blocked with a phase-change material (1-tetradecanol), which has a melting point of 38 – 39 à ¯Ã¢â‚¬Å¡Ã‚ °C. Below 1-tetradecanol’s melting point, it will be in a solid state to completely block the passing of encapsulated ibuprofen. When the temperature is raised beyond its melting point, it will quickly melt to release the encapsulated ibuprofen (heat control release). NIR light control release of doxorubicin in the [emailprotected]2@mSiO2 domains in the Janus nanocomposites: Upon absorption of NIR light (980 nm), the UCNPs emit photons in the UV/ Vis region, which can be absorbed immediately by the photo responsive azobenzene molecules. The reversible photoisomerization by simultaneous UV and visible light emitted by the UCNPs creates a continuous rotation–inversion movement, and the doxorubicin molecules can be released from the mesopores of [emailprotected]2@mSiO2. The necessary characterization (i.e. UV-Vis, FTIR, SEM, and TEM) will be used in the experiments.

A Child Called It Essay -- Child Abuse Essays Papers

A Child Called It As a child Dave Pelzer was brutally beaten and starved by his emotionally unstable, alcoholic mother; a mother who played tortuous, unpredictable games that left one of her sons nearly dead. She no longer considered him a son, but a slave; no longer a boy, but an 'it'. His bed was an old army cot in the basement, his clothes were torn and smelly, and when he was allowed the luxury of food it was scraps from the dogs' bowl. The outside world knew nothing of the nightmare played out behind closed doors. Dave dreamed of finding a family to love him and call him their son. It took years of struggle, deprivation and despair to find his dreams and make something of himself. A Child Called 'It' covers the early years of his life and is an affecting and inspiration memoir of one child's determination to survive. In most of my classes I’ve always heard that your parents are the most important people in your life and I truly believe this. People are affected by everything their parents say and do both in childhood and later on in adulthood. If a child is constantly looked down upon and made to believe that nothing they do is good enough, chances are they will grow up believing this and having low confidence. It is remarkable that a child David’s age fought himself from breaking down, dissolving into tears and giving up hope for a better future. David constantly worked towards or rather survived because of a dream, a dream t hat he was a prince and that every...

Illegal Drugs :: essays research papers

Illegal Drugs   Ã‚  Ã‚  Ã‚  Ã‚  The product is illegal drugs. The people who deal these drugs are criminals. That's what makes the drug business different then any other.   Ã‚  Ã‚  Ã‚  Ã‚  *Alcohol is a drug, yet adults are allowed to use alcohol products.   Ã‚  Ã‚  Ã‚  Ã‚  *Nicotine is a drug, yet adults are allowed to use many different forms of tobacco products, all   Ã‚  Ã‚  Ã‚  Ã‚  which have tobacco in them.   Ã‚  Ã‚  Ã‚  Ã‚  *The drug Caffeine can be found in many everyday items, like soda candy bars. Think of how   Ã‚  Ã‚  Ã‚  Ã‚  many cops we would need if caffeine products were illegal. Why are drugs like cocaine,marijuana and heroin illegal? Cocaine, marijuana and heroin are illegal because most people think that these controlled substances are simply to dangerous for anyone to use. They the effects of thes substances ruin the body and mind so badly and quickly that no one should try them.   Ã‚  Ã‚  Ã‚  Ã‚  We have law aginst drug is so that the people who use dangerous drugs are putting themselves at a very high risk. They risk their health and their lives. Since they are breaking laws they also but themselves at the risk of getting arrested. They risk their freedom and their future all for drugs.   Ã‚  Ã‚  Ã‚  Ã‚  Each year drug use is the cause of a large number of accidents at home in the office and on the road. Everybody pays the price of drug abuse: more cops and prisons more hospitols and treatment centers and many lives lost.   Ã‚  Ã‚  Ã‚  Ã‚  But drug users hurt themselves more than anybody because they are supporting violent crimes in the drug world.   Ã‚  Ã‚  Ã‚  Ã‚  Just by using drugs they become part of that drug world. They are already commiting acrime. But the relationship between drug use and crime often means that drug users go on to commit crimes like robbery,burglary,assult, and murder.   Ã‚  Ã‚  Ã‚  Ã‚  Drug addiction means that the brain is saying I need drugs now it must have drugs. This offten means that addicts commit crimes to get money for drugs.Studies show that drug use increases criminal behavior:   Ã‚  Ã‚  Ã‚  Ã‚  *64% of violent crimes involve someone on drugs.   Ã‚  Ã‚  Ã‚  Ã‚  *75% Of prison inmates have a drug use history. *24% of addicts start dealing drugs to support their habit. Studies also show that drugs play a big part in youth and crime:   Ã‚  Ã‚  Ã‚  Ã‚  *more than 83% of youth in prison have used drugs.   Ã‚  Ã‚  Ã‚  Ã‚  *40% of youth in prison for serious crimes were on drugs at the time of the crime.   Ã‚  Ã‚  Ã‚  Ã‚  *More than 40% of youth in prison used drugs befor the age of 12.   Ã‚  Ã‚  Ã‚  Ã‚  Armed patrols Search and destroy missions and helicopter surveillance. Sounds like americans at war, well this goes on every day on our own home soil and the battle fields are our national parks and forests and the enemy is

Pornography and Prostitution :: Exploratory Essays Research Papers

Pornography and Prostitution The topic that I have been researching for the past few weeks has been prostitution. It has been very interesting so far. The studies have shown just exactly what the problems with prostitution are. In some of the older books I read, historians were interested mainly in discussing the attitudes toward prostitution but in more recent work the focus has been on prostitutes themselves including their range of alternatives, their conditions of work, their health and life spans, their careers-and interaction between prostitutes and others, such as reformers, clients, or bosses. Studies about men and women, boys, and girls who have been involved in prostitution and/or pornography have revealed a lot. They are the hardest patients to treat. They say they want help, but nothing thatà ¾s done to help them out works. They run back. They just donà ¾t seem to want to change. Women who have been subjected to continuous abuse and victimization over which they have no control or understanding have developed a sense of psychological paralysis that prohibits their ability to do anything positive about further victimization. They believe they are unable to change their destructive behavior. They become entrapped in helplessness and hopelessness. They feel themselves to be out of control of their lives. Essentially, they have developed a chronic disorder as a result of their victimization and an inability to separate themselves from the sexual exploitation in order to make a better life for themselves.    In a recent study based on an analysis of 200 women street prostitutes, 78% reported starting prostitution as juveniles; and 68% were 16 or younger when they started prostitution. A majority of the juvenile prostitutes described family structures with the outward appearances of stability. Over three-fourths reported having a religious upbringing. Forty percent were raised by both mother and father. The younger the prostitute, the more educated the family. Yet, despite the religious, financial, and other appearances of success, the study revealed a number of problems occurring within the family. More than half the prostitutes had parents involved in excessive drinking. In over half the families the child saw the father hit the mother violently and 62% of the subjects were themselves beaten while growing up. Only in a few cases was the beating related to something the subject did. The most damaging psychologically are those cases in which the victims could not figure out why they were being beaten or those in which they were being beaten for no special reason.

Jose Rizal, our national hero Essay

  Jose Rizal, our national hero was one of the Filipinos who asked for reformsduring the Spanish era. This was one of his best contributions in building our nation. These reforms will grant the ultimate dream of the reformists; assimilation. Filipinoswill be given the rights that they deserve. Rizal choose to seek for reforms than tostart a revolution because he knew that Philippines was not yet ready to stand onits own (during his time). Rizal used his liberal ideas in asking for reforms 5. Although Rizal hadrevolutionary ideas, he was not for armed revolution per se. He was more for thegradual and peaceful one. One that is catalyzed by the education of the Filipinopeople. He reasoned out that when subject people are educated, intelligent, and havebecome aware of their human rights, they would have self-determination and they would strive to be free from their mother country. When this revolution happens,drastic changes will occur in the political, economical, social, religious, andintelligence sphere of a society paving the way for its independence someday. Rizal reasoned out that when subject people are educated, intelligent, andhave become aware of their human rights, they would have self-determination andthey would strive to be free from their mother country. When this revolutionhappens, drastic changes will occur in the political, economical, social, religious,and intelligence sphere of a society paving the way for its independence someday.Even though Rizal did not actually support the revolution, we can say that healso contributed in this revolution. His works and writings were the corner stone of the revolution and he was indeed an inspiration for the Katipuneros during thosetimes. Rizal’s life was devoted to his country (Philippines). MIDTERM 1.Rizal shows his concern for a world community. This new order consists of nations which reaffirm faith in fundamental human rights, in the dignity and worth of the human person, in the equal rights of men and women . the nations would establish conditions of justice, social progress and better standards of life in larger freedom . the people would practice tolerance , live together in peace and maintain good relations among themselves 2. 3 â€Å"To the Filipino Youth† does carry a very strong one; strong enough to persuade those who are to be persuaded-the Filipino youth themselves. As one of those individuals, I could really feel the nationalistic spirit within me glow brighter the moment I finished reading the poem. It was like telling me that I am one of the existing hopes of our dear country and that through my abilities, expertise and knowledge of things, I am capable of protecting its freedom against oppressive forces that may come through. Furthermore, it was like telling me that together with my fellow youths, I am responsible for preserving the Philippines as a nation not for the foreigners but for me and the rest of the Filipinos. Finally yet most importantly, as to the sincerity of the poem, I can really consider â€Å"To the Filipino Youth† as indeed a work from the heart-no pretense, no plasticity and no sort of hidden motives. I can tell it so based on what I felt when I was reading the poem and the emotions that were expressed on each of the poem’s line. The fact that it came out during the Spanish era was also another thing that made me think that way. SEMIFINALS 1. If you don’t have a good EDUCATION system,   your MOTHERLAND is lacking in luster. the KEY is that RIZAL isn’t praising the Filipino education system †¦ he’s describing an ideal system and IS VERY CAREFUL NOT TO SUGGEST that it’s the one he came out of. 2. The first step carrying out his education philosophy is depends on mother. Rizal appealed to all mothers to do their best in educating their children. Love for honor, sincere and firm character, clear mind , clean conduct, noble action, love for one’s fellowmen, respect for God. The country should not expect honor and prosperity so long as the education of the child is defective.